Protein Modification Reagents
eMolecules 50586-80-6 | M-PEG3-TOS | AstaTech | MFCD13184964 | 274.330 | C12H18O5S | 95.000 | COCCOCCOS(=O)(=O)c1ccc(C)cc1 | 1g | 402181567
M-PEG3-TOS | AstaTech | 50586-80-6 | MFCD13184964 | 274.330 | C12H18O5S | 95.000 | COCCOCCOS(=O)(=O)c1ccc(C)cc1 | 1g | 402181567
eMolecules 31127-85-2 | Bis-PEG4-acid | Ambeed | MFCD22201545 | 294.300 | C12H22O8 | 97.000 | OC(=O)CCOCCOCCOCCOCCC(O)=O | 25g | 823414862
Bis-PEG4-acid | Ambeed | 31127-85-2 | MFCD22201545 | 294.300 | C12H22O8 | 97.000 | OC(=O)CCOCCOCCOCCOCCC(O)=O | 25g | 823414862
Medchemexpress LLC Biotin-PEG4-acid | 721431-18-1 | 97.0% | 1 G
Biotin-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed to harness the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. They consist of two distinct ligands connected by a linker, with one ligand targeting an E3 ubiquitin ligase and the other targeting a protein of interest.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Facilitates selective degradation of target proteins
- Engages the ubiquitin-proteasome system
Medchemexpress LLC NH-bis(C2-PEG2-NH-Boc) | 2182601-69-8 | 99.9% | 50 MG
NH-bis(C2-PEG2-NH-Boc) is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed to contain two different ligands connected by a linker, allowing for the exploitation of the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in the synthesis of PROTACs.
- Functions as a PEG-based PROTAC linker.
- Targets PROTAC linkers and PROTAC pathways.
- Applicable in cancer-programmed cell death.
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC Dbco-PEG4-VC-PAB-MMAE | 2129164-91-4 | 99.2% | 1658.03 | C88H128N12O19 | 25 MG
DBCO-PEG4-VC-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) synthesis and click-chemistry bioconjugation. It combines a DBCO click handle, a PEG4 spacer, a Val-Cit-PAB cleavable linker, and an MMAE cytotoxic payload, and is supplied as a solid powder for laboratory use.
- Contains a DBCO handle for strain-promoted alkyne-azide cycloaddition (SPAAC).
- Includes a hydrophilic PEG4 spacer to improve solubility and reduce aggregation.
- Features a valine-citrulline (Val-Cit) peptide and para-aminobenzyl (PAB) self-immolative linker for enzymatic cleavage.
- Delivers an MMAE warhead suitable for construction of cleavable ADCs.
- Supplied as a white to off-white solid with recommended storage at -20°C and limited stability in solution.
Medchemexpress LLC VH032-PEG5-C6-Cl | 1799506-06-1 | 99.9% | 783.41 | 25 MG
VH032-PEG5-C6-Cl (HaloPROTAC 2) is a conjugate of ligands for E3 and a 21-atom-length linker. It incorporates a VH032-based VHL ligand and a 5-unit PEG linker, capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.
- Target: VHL
- Activity: Induces nearly 70% degradation of GFP-Halotag7 at 2.5 μM after 24 hours of treatment in in vitro assays
- Application: For research use only
Medchemexpress LLC Dbco-(peg2-vc-pab-mmae)2 | 2259318-55-1 | 99.2% | 2835.50 g·mol⁻¹ | C149H224N22O32 | 10 MG
DBCO-(PEG2-VC-PAB-MMAE)2 is a click-chemistry compatible ADC linker dimer that carries monomethyl auristatin E (MMAE) payloads on a cleavable Val-Cit-PAB spacer and features a DBCO handle for strain-promoted alkyne-azide cycloaddition (SPAAC). It is used for bioconjugation and synthesis of antibody-drug conjugates, enabling controlled intracellular release of MMAE via protease cleavage.
- Enables strain-promoted alkyne-azide cycloaddition for copper-free bioconjugation.
- Includes a Val-Cit-PAB protease-cleavable linker for intracellular payload release.
- Delivers MMAE warheads for potent tubulin inhibition after release.
- Available as a powder with multiple package sizes for research-scale synthesis.
- High supplied purity supports reliable conjugation and analytical characterization.
Medchemexpress LLC Mal-PEG4-Val-Cit-PAB | 1949793-41-2 | 98.9% | 777.86 | C36H55N7O12 | 5 MG
Mal-PEG4-Val-Cit-PAB is a cleavable antibody-drug conjugate (ADC) linker that contains a maleimide reactive group, a four-unit polyethylene glycol (PEG4) spacer, a valine-citrulline (Val-Cit) dipeptide, and a para-aminobenzyl (PAB) self-immolative spacer. It is used in the synthesis of ADCs to enable protease-triggered release of cytotoxic payloads.
- Cleavable linker for protease-triggered payload release.
- Contains maleimide functional group for thiol conjugation.
- PEG4 spacer to improve solubility and reduce aggregation.
- Val-Cit-PAB motif enables self-immolation and controlled payload release.
- High purity (98.9%) and characterized molecular weight 777.86.
- Available in a 5 mg vial for research use.
(C)C(C)(C)C)OCCC#N | 500mg | 550804124](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203158.JPG-250.jpg)
eMolecules 1807521-08-9 | TBDMS-PEG5-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite | Broadpharm | MFCD28142479 | 508.712 | C23H49N2O6PSi | 98.000 | CC(C)N(C(C)C)P(OCCOCCOCCOCCO[Si](C)(C)C(C)(C)C)OCCC#N | 500mg | 550804124
TBDMS-PEG5-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite | Broadpharm | 1807521-08-9 | MFCD28142479 | 508.712 | C23H49N2O6PSi | 98.000 | CC(C)N(C(C)C)P(OCCOCCOCCOCCO[Si](C)(C)C(C)(C)C)OCCC#N | 500mg | 550804124
Medchemexpress LLC Propargyl-PEG4-5-nitrophenyl carbonate | 1422540-81-5 | 98.19% | 397.38 | 25 MG
Propargyl-PEG4-5-nitrophenyl carbonate is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It acts as a click chemistry reagent, possessing an Alkyne group that enables it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs consist of two distinct ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein, facilitating the selective degradation of target proteins via the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
eMolecules 32130-27-1 | m-PEG36-amine | Broadpharm | MFCD21363226 | 1616.966 | C73H149NO36 | 97.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN | 500mg | 229582608
m-PEG36-amine | Broadpharm | 32130-27-1 | MFCD21363226 | 1616.966 | C73H149NO36 | 97.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN | 500mg | 229582608
![eMolecules 1807512-36-2 | Azido-PEG3-(CH2)3OH | Broadpharm | MFCD28950754 | 233.268 | C9H19N3O4 | 98.000 | OCCCOCCOCCOCCN=[N+]=[N-] | 500mg | 550804232](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203230.JPG-250.jpg)
eMolecules 1807512-36-2 | Azido-PEG3-(CH2)3OH | Broadpharm | MFCD28950754 | 233.268 | C9H19N3O4 | 98.000 | OCCCOCCOCCOCCN=[N+]=[N-] | 500mg | 550804232
Azido-PEG3-(CH2)3OH | Broadpharm | 1807512-36-2 | MFCD28950754 | 233.268 | C9H19N3O4 | 98.000 | OCCCOCCOCCOCCN=[N+]=[N-] | 500mg | 550804232
Medchemexpress LLC Tos-PEG5-CH2COOtBu | 1949793-62-7 | C23H38O10S | 250 MG
Tos-PEG5-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is associated with applications in cancer-programmed cell death, and its target is PROTAC Linkers.
- Used in the synthesis of PROTACs.
- Associated with applications in cancer-programmed cell death.
- Target is PROTAC linkers.
Medchemexpress LLC M-PEG4-PFP ester | 2952895-31-5 | 98.0% | 402.31 | 25 MG
M-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- Molecular weight: 402.31
- Formula: C16H19F5O6
- Appearance: Liquid
- Color: Colorless to light yellow
- Solubility in DMSO: ≥ 100 mg/mL (248.56 mM)
Medchemexpress LLC DSPE-N3 | 2839508-98-2 | 96.4% | 831.11 g/mol | C43H83N4O9P | 50 MG
DSPE-N3 is an azide-functionalized phospholipid used as a click-chemistry reagent for biochemical research. It enables covalent conjugation via azide-alkyne cycloaddition and is commonly used to functionalize liposomes, nanoparticles, and biomolecules for labeling or targeted delivery applications.
- Contains an azide functional group for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) for copper-free reactions.
- Suitable for liposome and surface functionalization in biochemical studies.
- Supplied as a white to off-white solid with high purity.
- Soluble in DMSO (12.5 mg/mL) with sonication and heating.
- Recommend sealed storage at 4°C; in solution: -80°C (6 months), -20°C (1 month).